https://sciencenode-dll.npub.pro/author/npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue/ https://sciencenode-dll.npub.pro/author/npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue/rss/ episodic Sat, 31 May 2025 18:18:11 GMT Sat, 31 May 2025 18:18:11 GMT https://sciencenode-dll.npub.pro/author/npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue/ https://nostrcheck.me/media/134743ca8ad0203b3657c20a6869e64f160ce48ae6388dc1f5ca67f346019ee7/2d3d2cdfd2f8f53c00263a9e903e33be483f7ef8ec1137b03c1d5d9de6fd8733.webp Sat, 31 May 2025 18:18:11 GMT https://sciencenode-dll.npub.pro/post/note1nc4qfgaagsksqt7avvkufx2dht6c0e8lcugthye2c6jrtzksr7lqchylrs/ https://sciencenode-dll.npub.pro/post/note1nc4qfgaagsksqt7avvkufx2dht6c0e8lcugthye2c6jrtzksr7lqchylrs/ note1nc4qfgaagsksqt7avvkufx2dht6c0e8lcugthye2c6jrtzksr7lqchylrs note1nc4qfgaagsksqt7avvkufx2dht6c0e8lcugthye2c6jrtzksr7lqchylrs npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue It's almost as if this could have been predicted.

After firing the CDC lead poisoning…

]]> It's almost as if this could have been predicted.

After firing the CDC lead poisoning…

]]> Sat, 31 May 2025 16:07:55 GMT https://sciencenode-dll.npub.pro/post/note14x89wg3jjh3m8v8my4pjycmcmpnwn5zqjf4c29v49tutvn56fpyqzkwv2j/ https://sciencenode-dll.npub.pro/post/note14x89wg3jjh3m8v8my4pjycmcmpnwn5zqjf4c29v49tutvn56fpyqzkwv2j/ note14x89wg3jjh3m8v8my4pjycmcmpnwn5zqjf4c29v49tutvn56fpyqzkwv2j note14x89wg3jjh3m8v8my4pjycmcmpnwn5zqjf4c29v49tutvn56fpyqzkwv2j npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue Minor hiccup truncating responses has been resolved. Please submit your own feedback to continually improve the AI.




Get a taste of the Surgeon…

]]> Minor hiccup truncating responses has been resolved. Please submit your own feedback to continually improve the AI.




Get a taste of the Surgeon…

]]> Tue, 20 May 2025 17:59:38 GMT https://sciencenode-dll.npub.pro/post/note16uxemp7td4vxlyks7wza9qdlsf4aewk64l2jkt6s0uqzunmlaajqn3phdd/ https://sciencenode-dll.npub.pro/post/note16uxemp7td4vxlyks7wza9qdlsf4aewk64l2jkt6s0uqzunmlaajqn3phdd/ note16uxemp7td4vxlyks7wza9qdlsf4aewk64l2jkt6s0uqzunmlaajqn3phdd note16uxemp7td4vxlyks7wza9qdlsf4aewk64l2jkt6s0uqzunmlaajqn3phdd npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue Kennedy's incorrigible ignorance is metastasizing.

]]> Kennedy's incorrigible ignorance is metastasizing.

]]> Mon, 19 May 2025 19:49:48 GMT https://sciencenode-dll.npub.pro/post/note1595zdnhljtn7kk6ahcrk8jvhjfgedp54hcqgx9fzkzknq6y7dfrq24uw4k/ https://sciencenode-dll.npub.pro/post/note1595zdnhljtn7kk6ahcrk8jvhjfgedp54hcqgx9fzkzknq6y7dfrq24uw4k/ note1595zdnhljtn7kk6ahcrk8jvhjfgedp54hcqgx9fzkzknq6y7dfrq24uw4k note1595zdnhljtn7kk6ahcrk8jvhjfgedp54hcqgx9fzkzknq6y7dfrq24uw4k npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐨𝐟 𝐀𝐂𝐄𝐢 (A) The natural peptide SQ 20881 (sequence EWPRPQIPP), discovered in Bothrops jararaca venom, is an inhibitor of ACE, inducing a drop in blood pressure. Squibb company synthetized a derivative which led, after optimization, to the captopril (1981). Because of the side effects of the thiol group, Merck replaced the latter with a carboxylate, resulting in the enalaprilat molecule (1985). However, as this modification resulted in the loss of oral bioavailability, the esterification of the enalaprilat was considered by Merck to solve the problem successfully and created the enalapril (1985). (B) Interaction between captopril and ACE. By preventing the binding of the inert Angiotensin I to ACE, captopril inhibits the formation of Angiotensin II.

]]> 𝐃𝐞𝐯𝐞𝐥𝐨𝐩𝐦𝐞𝐧𝐭 𝐨𝐟 𝐀𝐂𝐄𝐢 (A) The natural peptide SQ 20881 (sequence EWPRPQIPP), discovered in Bothrops jararaca venom, is an inhibitor of ACE, inducing a drop in blood pressure. Squibb company synthetized a derivative which led, after optimization, to the captopril (1981). Because of the side effects of the thiol group, Merck replaced the latter with a carboxylate, resulting in the enalaprilat molecule (1985). However, as this modification resulted in the loss of oral bioavailability, the esterification of the enalaprilat was considered by Merck to solve the problem successfully and created the enalapril (1985). (B) Interaction between captopril and ACE. By preventing the binding of the inert Angiotensin I to ACE, captopril inhibits the formation of Angiotensin II.

]]> Thu, 15 May 2025 12:50:13 GMT https://sciencenode-dll.npub.pro/post/note1cappq47sj9t78s2g8enqsrnv4qpa38yh7syxrkjjuttmyslfnutqa2ejtr/ https://sciencenode-dll.npub.pro/post/note1cappq47sj9t78s2g8enqsrnv4qpa38yh7syxrkjjuttmyslfnutqa2ejtr/ note1cappq47sj9t78s2g8enqsrnv4qpa38yh7syxrkjjuttmyslfnutqa2ejtr note1cappq47sj9t78s2g8enqsrnv4qpa38yh7syxrkjjuttmyslfnutqa2ejtr npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue ]]> ]]> Wed, 14 May 2025 04:08:01 GMT https://sciencenode-dll.npub.pro/post/note1xqcmgkepk4uvy2phnfpgxtqqz0n7wz2wj3jue6m5mk5633hvqx4q0x4gy7/ https://sciencenode-dll.npub.pro/post/note1xqcmgkepk4uvy2phnfpgxtqqz0n7wz2wj3jue6m5mk5633hvqx4q0x4gy7/ note1xqcmgkepk4uvy2phnfpgxtqqz0n7wz2wj3jue6m5mk5633hvqx4q0x4gy7 note1xqcmgkepk4uvy2phnfpgxtqqz0n7wz2wj3jue6m5mk5633hvqx4q0x4gy7 npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue ]]> ]]> Mon, 12 May 2025 16:51:21 GMT https://sciencenode-dll.npub.pro/post/note1mdavznwjsk22lrzg6e045jk83re5cznsqltkp8sgsjtudumvfchs8xzf8d/ https://sciencenode-dll.npub.pro/post/note1mdavznwjsk22lrzg6e045jk83re5cznsqltkp8sgsjtudumvfchs8xzf8d/ note1mdavznwjsk22lrzg6e045jk83re5cznsqltkp8sgsjtudumvfchs8xzf8d note1mdavznwjsk22lrzg6e045jk83re5cznsqltkp8sgsjtudumvfchs8xzf8d npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue Cholera outbreak in Angola kills nearly 600 people

]]> Cholera outbreak in Angola kills nearly 600 people

]]> Sun, 11 May 2025 05:10:51 GMT https://sciencenode-dll.npub.pro/post/note13z3zx9f4pd7kny5jtek7zrahtdxz2yra04v0u05lxt5x0cl0wtrq5uya49/ https://sciencenode-dll.npub.pro/post/note13z3zx9f4pd7kny5jtek7zrahtdxz2yra04v0u05lxt5x0cl0wtrq5uya49/ note13z3zx9f4pd7kny5jtek7zrahtdxz2yra04v0u05lxt5x0cl0wtrq5uya49 note13z3zx9f4pd7kny5jtek7zrahtdxz2yra04v0u05lxt5x0cl0wtrq5uya49 npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue The kinetoplastids are so called because of the mitochondria-like kinetoplast found near the flagellar basal body. A B C & D depict their developmental stages. The cutaneous manifestation of Leishmaniasis recently reported in Venezuela is spread by sandfly bites.

Map: https://www.researchgate.net/publication/311500121_Diagnosis_and_Treatment_of_Leishmaniasis_Clinical_Practice_Guidelines_by_the_Infectious_Diseases_Society_of_America_IDSA_and_the_American_Society_of_Tropical_Medicine_and_Hygiene_ASTMH

]]> The kinetoplastids are so called because of the mitochondria-like kinetoplast found near the flagellar basal body. A B C & D depict their developmental stages. The cutaneous manifestation of Leishmaniasis recently reported in Venezuela is spread by sandfly bites.

Map: https://www.researchgate.net/publication/311500121_Diagnosis_and_Treatment_of_Leishmaniasis_Clinical_Practice_Guidelines_by_the_Infectious_Diseases_Society_of_America_IDSA_and_the_American_Society_of_Tropical_Medicine_and_Hygiene_ASTMH

]]> Sat, 10 May 2025 09:17:10 GMT https://sciencenode-dll.npub.pro/post/note1ekeycmfjgcj22ar0ncm7tdpmwz4rswmmfujszjf8p5tl4h4w372q6l4hs4/ https://sciencenode-dll.npub.pro/post/note1ekeycmfjgcj22ar0ncm7tdpmwz4rswmmfujszjf8p5tl4h4w372q6l4hs4/ note1ekeycmfjgcj22ar0ncm7tdpmwz4rswmmfujszjf8p5tl4h4w372q6l4hs4 note1ekeycmfjgcj22ar0ncm7tdpmwz4rswmmfujszjf8p5tl4h4w372q6l4hs4 npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue Get a taste of the Surgeon General nominee's education with this Mini Med School chatbot we're refining.

Obviously, but importantly: this embryonic AI does not claim/attempt to replace real licensed experts, resources, or experience.

Send us a message or comment regarding feedback, bugs and suggestions you may find so that we can further refine it.
https://aistudio.instagram.com/ai/982093260737180/

]]> Get a taste of the Surgeon General nominee's education with this Mini Med School chatbot we're refining.

Obviously, but importantly: this embryonic AI does not claim/attempt to replace real licensed experts, resources, or experience.

Send us a message or comment regarding feedback, bugs and suggestions you may find so that we can further refine it.
https://aistudio.instagram.com/ai/982093260737180/

]]> Wed, 07 May 2025 19:01:23 GMT https://sciencenode-dll.npub.pro/post/note1h63jp07v0jhhlxjuchxrmh53wut4j3avmza9r0g8tk3ypj0zjp2qkd9zhd/ https://sciencenode-dll.npub.pro/post/note1h63jp07v0jhhlxjuchxrmh53wut4j3avmza9r0g8tk3ypj0zjp2qkd9zhd/ note1h63jp07v0jhhlxjuchxrmh53wut4j3avmza9r0g8tk3ypj0zjp2qkd9zhd note1h63jp07v0jhhlxjuchxrmh53wut4j3avmza9r0g8tk3ypj0zjp2qkd9zhd npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue ]]> ]]> Tue, 06 May 2025 18:46:34 GMT https://sciencenode-dll.npub.pro/post/note13wqp4urs6xdtnr8nzm0vyyhgxrsmvg5r5408krc9lrv7fa2d8hqqv2awer/ https://sciencenode-dll.npub.pro/post/note13wqp4urs6xdtnr8nzm0vyyhgxrsmvg5r5408krc9lrv7fa2d8hqqv2awer/ note13wqp4urs6xdtnr8nzm0vyyhgxrsmvg5r5408krc9lrv7fa2d8hqqv2awer note13wqp4urs6xdtnr8nzm0vyyhgxrsmvg5r5408krc9lrv7fa2d8hqqv2awer npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue This is who wants to dismantle education.

]]> This is who wants to dismantle education.

]]> Mon, 05 May 2025 14:47:38 GMT https://sciencenode-dll.npub.pro/post/note1lrct0syzcw8awlv82vkqy0rclcka5gec8efr2a5luejssmvdvqxsynt3gt/ https://sciencenode-dll.npub.pro/post/note1lrct0syzcw8awlv82vkqy0rclcka5gec8efr2a5luejssmvdvqxsynt3gt/ note1lrct0syzcw8awlv82vkqy0rclcka5gec8efr2a5luejssmvdvqxsynt3gt note1lrct0syzcw8awlv82vkqy0rclcka5gec8efr2a5luejssmvdvqxsynt3gt npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue Under Bigotocracy, truck drivers need to be more literate than the head of HHS.

]]> Under Bigotocracy, truck drivers need to be more literate than the head of HHS.

]]> Tue, 22 Apr 2025 17:07:29 GMT https://sciencenode-dll.npub.pro/post/note1vf0zs5lhkasr42sh8vaae93053fmcqdn0f0n8fqecmmcfmycdzps8c045q/ https://sciencenode-dll.npub.pro/post/note1vf0zs5lhkasr42sh8vaae93053fmcqdn0f0n8fqecmmcfmycdzps8c045q/ note1vf0zs5lhkasr42sh8vaae93053fmcqdn0f0n8fqecmmcfmycdzps8c045q note1vf0zs5lhkasr42sh8vaae93053fmcqdn0f0n8fqecmmcfmycdzps8c045q npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue ]]> ]]> Fri, 18 Apr 2025 19:28:41 GMT https://sciencenode-dll.npub.pro/post/note18mrdcftnrhlt03nze7jfvggs5wp08zya4wqcw3flkugjjdwmet8q7nr6dp/ https://sciencenode-dll.npub.pro/post/note18mrdcftnrhlt03nze7jfvggs5wp08zya4wqcw3flkugjjdwmet8q7nr6dp/ note18mrdcftnrhlt03nze7jfvggs5wp08zya4wqcw3flkugjjdwmet8q7nr6dp note18mrdcftnrhlt03nze7jfvggs5wp08zya4wqcw3flkugjjdwmet8q7nr6dp npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue ]]> ]]> Sat, 12 Apr 2025 16:47:22 GMT https://sciencenode-dll.npub.pro/post/note1aeca5kw9cuzhedfvz2y370r4sk95uhwr34g32rs5dxay7yqevrlqmysdwe/ https://sciencenode-dll.npub.pro/post/note1aeca5kw9cuzhedfvz2y370r4sk95uhwr34g32rs5dxay7yqevrlqmysdwe/ note1aeca5kw9cuzhedfvz2y370r4sk95uhwr34g32rs5dxay7yqevrlqmysdwe note1aeca5kw9cuzhedfvz2y370r4sk95uhwr34g32rs5dxay7yqevrlqmysdwe npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue After firing the CDC lead poisoning experts amid a Milwaukee lead poisoning crisis, RFK Jr. has fired the CDC's cruise ship inspectors amid a bad year for outbreaks, despite cruise ships being a prime breeding ground for infectious diseases.

]]> After firing the CDC lead poisoning experts amid a Milwaukee lead poisoning crisis, RFK Jr. has fired the CDC's cruise ship inspectors amid a bad year for outbreaks, despite cruise ships being a prime breeding ground for infectious diseases.

]]> Wed, 09 Apr 2025 03:34:54 GMT https://sciencenode-dll.npub.pro/post/note1vlw4d2ykemwsu6v77p2lswawt83rg32cmps54j75xvt9hwyg9q6sg0jp9m/ https://sciencenode-dll.npub.pro/post/note1vlw4d2ykemwsu6v77p2lswawt83rg32cmps54j75xvt9hwyg9q6sg0jp9m/ note1vlw4d2ykemwsu6v77p2lswawt83rg32cmps54j75xvt9hwyg9q6sg0jp9m note1vlw4d2ykemwsu6v77p2lswawt83rg32cmps54j75xvt9hwyg9q6sg0jp9m npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue The Trump administration installed DOGE operative Scott Coulter as the new Chief Information Officer (CIO) of the Social Security Administration (SSA) to evade a federal court order blocking DOGE affiliates from dismantling Social Security.

]]> The Trump administration installed DOGE operative Scott Coulter as the new Chief Information Officer (CIO) of the Social Security Administration (SSA) to evade a federal court order blocking DOGE affiliates from dismantling Social Security.

]]> Sat, 29 Mar 2025 22:00:41 GMT https://sciencenode-dll.npub.pro/post/note137jk0xpxzdspk0c9rtxjthsjaqm2umedn84wvndgu25ynk0zr0pqddcufl/ https://sciencenode-dll.npub.pro/post/note137jk0xpxzdspk0c9rtxjthsjaqm2umedn84wvndgu25ynk0zr0pqddcufl/ note137jk0xpxzdspk0c9rtxjthsjaqm2umedn84wvndgu25ynk0zr0pqddcufl note137jk0xpxzdspk0c9rtxjthsjaqm2umedn84wvndgu25ynk0zr0pqddcufl npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue thalidomide acts by promoting the degradation of an unexpectedly wide range of transcription factors – cell proteins that help switch genes on or off – including one called SALL4
https://www.dana-farber.org/newsroom/news-releases/2018/after-60-years-scientists-uncover-how-thalidomide-produced-birth-defects

]]> thalidomide acts by promoting the degradation of an unexpectedly wide range of transcription factors – cell proteins that help switch genes on or off – including one called SALL4
https://www.dana-farber.org/newsroom/news-releases/2018/after-60-years-scientists-uncover-how-thalidomide-produced-birth-defects

]]> Sun, 23 Mar 2025 04:06:40 GMT https://sciencenode-dll.npub.pro/post/note16ru4c2zpcghgv426mn3s235g63u3lqa6t4f54jljyw98n0dtw3csdgqglm/ https://sciencenode-dll.npub.pro/post/note16ru4c2zpcghgv426mn3s235g63u3lqa6t4f54jljyw98n0dtw3csdgqglm/ note16ru4c2zpcghgv426mn3s235g63u3lqa6t4f54jljyw98n0dtw3csdgqglm note16ru4c2zpcghgv426mn3s235g63u3lqa6t4f54jljyw98n0dtw3csdgqglm npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue וגם לרופא תן מקום, ולא ימוש כי גם בו צורך. כי יש עתם אשר בידו מצלחת, כי גם הוא אל אל יעתיר. אשר יצלח לו פשרה, ורפאות למען מחיה.

]]> וגם לרופא תן מקום, ולא ימוש כי גם בו צורך. כי יש עתם אשר בידו מצלחת, כי גם הוא אל אל יעתיר. אשר יצלח לו פשרה, ורפאות למען מחיה.

]]> Thu, 13 Mar 2025 15:55:46 GMT https://sciencenode-dll.npub.pro/post/note17jq5zv42xmlaxvhxuynw0vlreca5sk7fq48snedvzsl5g6wq6kcs9svtyu/ https://sciencenode-dll.npub.pro/post/note17jq5zv42xmlaxvhxuynw0vlreca5sk7fq48snedvzsl5g6wq6kcs9svtyu/ note17jq5zv42xmlaxvhxuynw0vlreca5sk7fq48snedvzsl5g6wq6kcs9svtyu note17jq5zv42xmlaxvhxuynw0vlreca5sk7fq48snedvzsl5g6wq6kcs9svtyu npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue ]]> ]]> Sat, 08 Mar 2025 13:18:10 GMT https://sciencenode-dll.npub.pro/post/note1dtk96kw3t06z34372nrw3jt0rf9je5a3lgqje5swupv67n57qz0sfz0nxk/ https://sciencenode-dll.npub.pro/post/note1dtk96kw3t06z34372nrw3jt0rf9je5a3lgqje5swupv67n57qz0sfz0nxk/ note1dtk96kw3t06z34372nrw3jt0rf9je5a3lgqje5swupv67n57qz0sfz0nxk note1dtk96kw3t06z34372nrw3jt0rf9je5a3lgqje5swupv67n57qz0sfz0nxk npub1m9xycuavmp5dnfstnu95auld5cnwhcaqry94uvw6cvj06qnsx9rsd8yxue ]]> ]]>